国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 178-182.

• 论著 • 上一篇    下一篇

儿童先天性心脏病生物资源信息管理平台的建立

刘瀚旻, 谢 亮, 邓长飞, 代 礼, 毛 萌   

  1. 610041 成都，四川大学华西第二医院儿科（刘瀚旻，谢 亮，毛 萌）；妇儿疾病与出生缺陷教育部重点实验室（刘瀚旻，谢 亮，邓长飞，代 礼，毛 萌）；中国出生监测中心（邓长飞，代 礼）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 毛 萌

Developing the Bioinformation Managemant System for Congenital Cardiovascular Defects of Children

LIU Han-min, XIE Liang, DENG Chang-fei, DAI Li， MAO Men   

  1. Department of Pediatrics（LIU Han-min, XIE Liang, MAO Meng）， Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education（LIU Han-min, XIE Liang, DENG Chang-fei, DAI Li， MAO Meng）， National Center for Birth Defects Monitoring（DENG Chang-fei, DAI Li）, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15
  • Contact: Mao Meng

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摘要： 目的：建立用于先天性心脏病临床诊疗服务和病因学研究的生物资源信息管理平台。方法：募集健康妊娠妇女和妊娠有先天性心脏病胎儿的妇女，随访观察妊娠结局；问卷调查收集母亲妊娠期暴露情况，采集母婴生物标本。根据临床诊疗服务和病因研究需求设计系统功能，采用Caché数据库技术构建数据库，采用微软.NET软件开发前台应用程序。结果：基于多层浏览器/服务器模式的管理信息系统顺利实现了问卷数据、临床检查数据以及生物标本信息的查询、在线分析和综合管理。结论：集临床诊疗和专题研究数据为一体的信息管理平台可提升多源数据汇总分析能力，有助于开展多中心病因学研究。

关键词: 心脏缺损, 先天性, 管理信息系统, 数据库管理系统, 医师诊疗模式, 多中心研究, 信息存储和检索

Abstract: Objective： To develop a management information system（ＭＩＳ） which can be used in the clinical service and aetiological study of congenital heart defects（ＣＨＤ）. Methods： Healthy pregnant women and those who conceived CHD fetus were recruited in this study, and followed up till childbirth. Maternal exposures during pregnancy were obtained using questionnaire survey. Biospecimens of mothers and infants were also collected. The functions of MIS were defined based on the needs of clinical services and aetiological researches. Caché database technology was adopted to construct database, and the Microsoft. NET platform was used to develop program modules. Results： A multi?鄄layered browser/server system with functions of online data quering, analyzing and managing has been built to process data from different sources including questionnaire, clinical tests and biospecimens. Conclusions： Due to the integration of clinical and research data, this platform can improve the pool analysis of data from multiple sources, which benefits to the multicenter studies on the etiology of CHD.

Key words: Heart defects, congenital, Management information systems, Database management systems, Physician’s practice patterns, Multicenter study, Information storage and retrieval