国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 243-246.

• 综述 • 上一篇    下一篇

环境激素的毒害效应及其表观遗传机制

王祥川,孙 彬, 陈桂来, 郑凯迪, 李 云   

  1. 400716 重庆，西南大学动物科技学院 教育部淡水鱼类生殖与发育重点实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 李 云

Adverse Effects of Environmental Hormones and Epigenetics

WANG Xiang-chuan， SUN Bin， CHEN Gui-lai， ZHENG Kai-di， LI Yun   

  1. College of Animal Science and Technology， Southwest University， Chongqing 400716， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15
  • Contact: LI Yun

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摘要： 环境内分泌干扰化合物是指存在于生物的直接生存环境中，能够干扰生物正常内分泌并导致其功能异常的一些污染物，其中环境激素及其类似物对生物体的毒害影响最大。环境激素对生物个体的直接毒害作用包括生殖发育、神经内分泌、免疫系统及致癌致畸等方面，并且与发育源性疾病间有着密切的关系。表观遗传机制在环境激素的长期毒害效应——传代效应中始终发挥着重要作用。

关键词: 环境激素, 毒害效应, 发育源性成人疾病, 传代效应, 表观遗传

Abstract: Environmental endocrine disruptors are defined as some pollutants resided in the direct environment of organisms， which disrupt the normal endocrine function. Of these compounds， environmental hormones and their analogs can affect organisms enormously. In this review， we discussｅd the direct adverse effects of environmental estrogens， including the damages on reproduction and development， neuroendocrine，immune system， carcinogenic and teratogenic effects. And we introduced the relationship between environmental hormones and development?-origin of adult diseases. Epigenetics always play a key role in the long periods adverse effects, transgenerational effects， of environmental estrogens.

Key words: Environmental estrogens, Adverse effects, Development-origin of adult diseases, Transgenerational effects, Epigenetics