关键词: 出生缺陷, 样本采集, 样本管理, 规范化

Abstract: Congenital disorder usually refer to the condition where functional or structural abnormalities developed at or before the birth of a child. The incidence of this congenital disorder is very high in China， especially in economically underdeveloped areas. Mechanisms of most of these birth defects are unclear and not many effective treatments are available. Given the complex nature of various birth defects，we must optimize the study using a top-level design，with thorough consideration to normalize and standardize sample collection， sample storage and transportation. At the same time， we will utilize a modern information and database management system for the fast， easy and reliable access and sharing of accurate sample information within our groups， in order for the successful execution of the program.

Key words: Congenital disorder, Sample collection, Sample management, Normalization