国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2009, Vol. 28 ›› Issue (6): 374-376.

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妊娠期糖尿病发病机制的相关基因

陈元元;陈丹青   

  1. 310006 杭州，浙江大学医学院附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-11-15 发布日期:2009-11-15

Related Genes in Pathogenesis of Gestational Diabetes Mellitus

CHEN Yuan-yuan;CHEN Dan-qing   

  1. Women's Hospital， School of Medicine， Zhejiang University Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-11-15 Online:2009-11-15

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摘要： 妊娠期糖尿病（gestational diabetes mellitus， GDM）指在妊娠过程中首次出现或发现的任何程度的糖耐量异常。其病因及发病机制目前尚不完全清楚。既往研究表明：GDM可能是一组多基因遗传所致的异质性疾病，其发病机制涉及到糖代谢机制的每一个环节，相关基因可能包括葡萄糖激酶基因，肝细胞核因子基因，胰岛素受体底物基因多态性等。

关键词: 妊娠期糖尿病, 发病机制, 基因

Abstract: Gestational diabetes mellitus （GDM） is defined as glucose intolerance with onset or first recognition during pregnancy. The pathogenesis of the disease is still largely unknown. GDM is a polygenic disease，being considered to result from interaction between genetic and environmental risk factors. Any abnormalities of steps or phases of glycometabolism may result in gestational diabetes. Common variants in several candidate genes （e. g. Glucokinase， Hepatocyte nuclear factor-1alpha， Insulin receptor substrate gene）have been demonstrated to increase the risk of GDM. This review focuses on the genetics of GDM.

Key words: Gestational diabetes mellitus, Pathogenesis, Gene