国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2018, Vol. 37 ›› Issue (5): 414-416.

• 综述 • 上一篇    下一篇

多囊卵巢综合征病因学研究进展

赵甲维，李晓宁，黄炎清，汪亚南，杜耀武   

  1. 475000  开封，河南大学淮河临床学院（赵甲维，李晓宁，黄炎清，汪亚南），基础医学院（杜耀武）
  • 收稿日期:2018-04-08 修回日期:2018-07-19 出版日期:2018-09-15 发布日期:2018-09-15
  • 通讯作者: 杜耀武，E-mail：dyw711@henu.edu.cn E-mail:zhao1429102041@163.com

The Etiology of Polycystic Ovary Syndrome

ZHAO Jia-wei，LI Xiao-ning，HUANG Yan-qing，WANG Ya-nan，DU Yao-wu   

  1. Henan University，Kaifeng 475000，Henan Province，China
  • Received:2018-04-08 Revised:2018-07-19 Published:2018-09-15 Online:2018-09-15
  • Contact: DU Yao-wu，E-mail：dyw711@henu.edu.cn E-mail:zhao1429102041@163.com

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摘要： 多囊卵巢综合征（PCOS）是一种发病多因性、临床表现多样性的综合征，以高雄激素血症、持续性无排卵和卵巢多囊样改变等为主要表现的生殖内分泌紊乱性疾病。PCOS病因众多，病机复杂。普遍认为PCOS是多个微效基因与环境因素相互作用而引起的一种多基因遗传病。此外，某些药物（如抗癫痫药）对PCOS发病的影响也越来越显著，并且出生前的宫内环境与出生后的外界环境也对PCOS的形成产生一定的作用。另外，精神心理因素引起下丘脑-垂体-卵巢轴紊乱也可导致PCOS的发生。现就PCOS病因学进行综述。

关键词: 多囊卵巢综合征, 基因, 危险因素

Abstract: Polycystic ovary syndrome (PCOS) is a syndrome characterized by multiple causes, complicated pathogenesis and clinical manifestations. It is a reproductive endocrine disorder characterized by hyperandrogensim, persistent anovulation and ovarian polycystic changes. It is generally believed that PCOS is a polygenic genetic disease caused by the interaction of multiple microgenes and environmental factors. In addition, some drugs, such as antiepileptics, have more effects on the pathogenesis of PCOS. The intrauterine environment before birth and the external environment after birth also play a role in the pathogenesis of PCOS. Moreover，the disorder of hypothalamic-pituitary-ovarian axis caused by mental and psychological factors may also lead to the pathogenesis of PCOS. The research progress of the etiolog of PCOS is briefly discussed in this review.

Key words: Polycystic ovary syndrome, Genes, Risk factors