铁死亡在多囊卵巢综合征中的研究进展

doi:10.12280/gjszjk.20240328

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是一种常见于青春期及育龄期女性的代谢紊乱性生殖系统综合征，临床表现除排卵障碍、月经失调以及不孕外，多数患者往往同时出现胰岛素抵抗（insulin resistance，IR）、高雄激素血症（hyperandrogenemia，HA）和腹型肥胖等内分泌异常。铁死亡是一种铁依赖性极强、由脂质过氧化及氧化-抗氧化系统失衡介导的程序性细胞死亡方式，已逐渐成为生殖医学领域的研究热点。铁死亡与PCOS的相关性近年受到广泛关注，最新研究表明铁死亡可能参与调节PCOS相关代谢紊乱，并通过破坏卵母细胞质量和子宫胎盘功能来影响PCOS女性生殖机能。总结了铁死亡有关机制，系统探讨了铁死亡与PCOS病理生理的相关性及其在PCOS治疗方面的研究进展，以期进一步丰富和完善PCOS诊断防治和预后评估体系。

关键词: 铁死亡, 细胞死亡, 铁过载, 多囊卵巢综合征, 不育，女性

Abstract:

Polycystic ovary syndrome (PCOS) is a common metabolic disorder of the reproductive system in women of adolescent and childbearing age. In addition to ovulatory dysfunction, menstrual dysfunction and infertility, most patients suffer from endocrine abnormalities such as insulin resistance (IR), hyperandrogenemia (HA) and abdominal obesity. Ferroptosis, a highly iron-dependent programmed cell death mediated by the lipid peroxidation and the imbalance in the oxidative-antioxidant system is a hot research topic in reproductive medicine. The relevance of ferroptosis in PCOS has received much attention in recent years, and recent studies suggest that ferroptosis may be involved in the regulation of PCOS-associated metabolic disorders and affect reproductive function in women with PCOS by disrupting oocyte quality and uteroplacental function. To further enrich and improve the system of diagnosis, prevention, and prognosis assessment of PCOS, we summarize the mechanisms related to ferroptosis, systematically discusses the correlation between ferroptosis and the pathophysiology of PCOS, and its research progress in the treatment of PCOS.

Key words: Ferroptosis, Cell death, Iron overload, Polycystic ovary syndrome, Infertility, female

李轩昂, 王婷婷, 相珊, 赵帅, 连方. 铁死亡在多囊卵巢综合征中的研究进展[J]. 国际生殖健康/计划生育杂志, 2024, 43(5): 425-429.

LI Xuan-ang, WANG Ting-ting, XIANG Shan, ZHAO Shuai, LIAN Fang. Research Progress of Ferroptosis in Pathogenesis of Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(5): 425-429.

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