Abstract: Objective：To investigate the relationship between fertility stress and life quality in non-pregnant patients undergoing IVF-ET. Methods：The cross-sectional survey was carried out by studying the basic situation, the Fertility Question Inventory (FPI) scale and the Fertility Quality of Life (FertiQoL) scale among 351 non-pregnant patients with IVF-ET failures in our center from May 2017 to October 2017, including 104 non-pregnant patients underwent more than 3 times of transplantation and 247 non-pregnant patients underwent less than 3 times of transplantation. The fertility stress and life quality was described by FPI and FertiQoL, respectively. The correlation between fertility stress and life quality was explored using Pearson method. Results：The total score of FPI in non-pregnant patients underwent IVF-ET was 162.22±20.63, and the total score of FertiQoL was 58.79±12.79. There were no significant differences in the FPI total scores and sub-item score, and FertiQoL total score and sub-item score, between patients being transplanted more than 3 times and patients being transplanted less than 3 times (all P＞0.05). Pearson analysis showed that there was positive correlation between the childless stress score in FPI and the total score in FertiQoL (P＜0.05), and that there was negative correlation between other item score in FPI and the total score in FertiQoL (P＜0.05). Multiple linear regression analysis showed that fertility stress, age and literacy were the main factors of the life quality in patients with IVF-ET failures (F=9.140, R2=0.391, P＜0.01). Conclusions：The fertility stress of non-pregnant patients underwent IVF-ET is an important factor influencing the life quality. The greater the fertility stress, the lower the life quality. Should pay attention to the psychological pressure in those non-pregnant patients underwent IVF-ET failures, and improve their life quality by proactively releasing the fertility stress.

Key words: Fertilization in vitro, Embryo transfer, Embryo loss, Quality of life, Infertility stress