Abstract: Objective：To understand the history and current development of HPV vaccine, and to predict the trend of HPV vaccine. Methods：Using CNKI and WangFang databases, 1 584 articles from January 1995 to Septemper 2018 were retrieved. HPV vaccine-related literatures were exported in the format of refworks. The cluster view or timeline view was described on the author, institution, key words, term and category, which was based on the cluster analysis using CiteSpace software. Results：The number of literatures was significantly increased around 2006, fell slightly from 2010 to 2014, and increased again after 2014. Although research teams and institutions in this field were widely distributed, the extensive or detailed studies were from few institutions, and the cooperative study was much less. The research hot words were college student, human papillomavirus vaccine, influencing factors related to HPV vaccine, study related to HPV vaccine guideline and application of HPV vaccine in women. Conclusions：Study on HPV vaccine is still a hot topic although it went through 28 years. In the future, the diversified cooperation in different institutions or teams should be encouraged. It is necessary for those new researchers to understand the findings of core authors and the developing trend in this field.

Key words: Papillomavirus vaccines, CiteSpace, Visualization analysis, Knowledge graph