Abstract: Objective：To investigate the association between the polymorphisms of single nucleotide polymorphisms (SNPs) of interleukin-2 gene (IL-2), IL-2 receptor α gene (IL-2Rα) and the susceptibility to unexplained recurrent spontaneous abortion (URSA). Methods：Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analysis SNPs of IL-2 (rs6822844) G/T and IL-2Rα (rs2104286) A/G in 145 URSA cases (URSA group) and 220 nomal controls (control group). Results：The frequencies of rs2104286 allele A and genotype A/A were higher in the URSA group when compared with the control group (P＜0.05). The carriers of rs2104286 allele A increased two times of the risk of URSA (OR=2.06, 95%CI: 1.34～3.16, P=0.001), so did the rs2104286 genotype AA (OR=2.27, 95%CI: 1.40～3.68, P=0.001). The frequencies of rs6822844 genotype G/G in the two groups were all 100% (P＞0.05). Conclusions：Allele A of IL-2Rα (rs2104286) might confer the susceptibility to URSA in Zhejiang. IL-2 (rs6822844) had no association with URSA.

Key words: Abortion, habitual, Interleukin-2, Inter, leukin-2 receptor alpha subunit, Polymorphism, single nucleotide