Abstract:

The primitive neuroectodermal tumor (PNET) in female reproductive system is clinically rare. There is no standard treatment regimen, and the prognosis is very poor. We report one case of unusual ovarian PNET, menstrual abnormality was the main symptom. There was a history of uterine leiomyoma. The serum tumor markers were not significantly increased. Meanwhile, there was no abnormal imaging findings. On October 20, 2022, the laparoscopic total hysterectomy, bilateral salpingectomy and bilateral ovariectomy was given under endotracheal general anesthesia. Postoperative pathology confirmed the diagnosis of ovarian small round cell malignant tumor. After surgery, the alternating chemotherapy with vincristine, doxorubicin liposomes, cyclophosphamide-ifosfamide and etoposide was given 5 cycles and showed no recurrence. By summarizing the clinical characteristics of such a rare tumor, it aims to improve clinicians′ understanding of the disease, so as to provide early diagnosis and effective treatment, and to improve the survival of patients.

Key words: Neuroectodermal tumors, primitive, Ovarian neoplasms, Therapy, Prognosis, Case reports