Progress on the Relationship between Gut Microbiota and Pregnancy Complications

doi:10.12280/gjszjk.20230091

Abstract

Abstract:

The gut microbiota plays an important role in maintaining the normal physiological function of the host. Due to the particularity of pregnant women in circulation, endocrine, immune status and dietary structure, the composition and quantity of gut microbiota will also change accordingly to adapt to the physiology of pregnancy. Studies have found that the composition of the gut microbiota in pregnant women had a causal relationship with the occurrence of pregnancy complications, such as gestational diabetes mellitus, pre-eclampsia and premature. Specifically, the dysbiosis of the gut microbiota and the metabolites can damage intestinal barrier, aggravate local and systemic inflammation, then lead to insulin resistance, hyperglycemia, hypertension and other symptoms, and finally increase the risk of pregnancy complications. In addition, the gut microbiota-targeted strategies, such as probiotic supplementation and prebiotics intake, had therapeutic effects in improving the immune and metabolic status of the host, which may provide a feasible method for the prevention and adjuvant treatment of pregnancy complications.

Key words: Gastrointestinal microbiome, Pregnancy, Pregnancy complications, Diabetes, gestational, Pre-eclampsia, Premature birth

SONG Qiu-jin, QIAN Xiao-hong, CHEN Qian. Progress on the Relationship between Gut Microbiota and Pregnancy Complications[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(5): 409-413.

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