Clinical Research Status of Mosaic Embryo Transfer

doi:10.12280/gjszjk.20230248

Abstract

Abstract:

Mosaic embryo is the third type of embryo between euploid embryo and aneuploid embryo, which contains two or more genetically different cell lines. With the development of genetic technology, the next generation sequencing technology has a higher detection accuracy for mosaic embryos. The outcome of mosaic embryo transplantation is uncertain, and the rates of implantation failure and abortion are significantly higher than those of euploid embryo transplantation. There is still a great debate on whether mosaic embryo can be transferred. However, mosaic embryo transfer provides the possibility of fertility for patients with aneuploid embryos, so the studies with large sample and long-term follow-up will be the research hotspot. Although the Reproductive Medicine Branch of the Chinese Medical Association issued preimplantation genetic diagnosis / preimplantation genetic screening (PGD/PGS) guidelines in 2017-2018, there is still a lack of guidance on mosaic embryo transfer. This article reviews the current research status of mosaic embryo transfer.

Key words: Chimera, Embryo transfer, Prenatal diagnosis, Aneuploidy, Preimplantation genetic testing, In vitro fertilization

YAN Hui-hui, ZHANG Yun-shan. Clinical Research Status of Mosaic Embryo Transfer[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(6): 503-506.

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