Abstract: To multicellular organisms, it is very necessary for cellular function coordination to control cell proliferation and death. Cell apoptosis is just the most important pattern to limit the proliferation of abnormal cells. The female germ cell apoptosis is an important way for follicle recuitment, selection and dominance. Recently，the research spots on oocyte apoptosis are the regulation mechanisms of Bcl-2 family, and its impact on embryo development.

Key words: Oocytes, Apoptosis, Genes, regulator, Embryonic and fetal development