Abstract: Pregnancy immune tolerance is a special type of immunological tolerance formed by maternal immune system during pregnancy. The status of immunological tolerance within maternal?-fetal interface is very important for maintaining pregnancy. The chemokines and their receptors expressed in maternal?fetal interface play important roles in the induced immune tolerance， participating in the invasion of trophoblasts，activation and migration of immunocytes. Stromal cell-derived factor-1（CXCL12）， monocyte chemotactic protein-1（CCL2）， and the regulated upon activation normal T cell expressed and secreted（RANTES）， belong to the super family of chemokines. In this article， we reviewed the effects of those chemokines and their receptors in the pregnancy immune tolerance.

Key words: Chemokine CXCL12, Chemokine CCL2, Chemokine CCL5, Receptors, chemokine, Immune tolerance