外阴阴道壁血管肌纤维母细胞瘤二例及文献复习

doi:10.12280/gjszjk.20200473

摘要/Abstract

摘要：

血管肌纤维母细胞瘤(angiomyofibroblastoma,AMF)是一种罕见的良性软组织肿瘤,主要来源于盆腔软组织间叶细胞。好发于女性,临床表现无特异性,影像学检查使用率低且术前难以确诊,需依靠病理学明确诊断。一般以手术治疗为主,预后良好,复发率极低。现报告2例外阴阴道壁血管肌纤维母细胞瘤病例,探讨该病的临床特点、病理及免疫组化特征、诊治方法及预后情况,并回顾相关文献,加深对该病的认识。

关键词: 肿瘤,肌组织, 外阴, 阴道, 免疫组织化学, 病例报告, 血管肌纤维母细胞瘤

Abstract:

Angiomyofibroblastoma (AMF) as a rare benign soft-tissue tumor is mainly caused by the interstitial cells of the pelvic soft tissue. It tends to occur in women, with non-specific clinical manifestations, low rate of imaging examination and difficulty in preoperative diagnosis. The clear diagnosis is dependent on pathology. Generally, surgery is the main treatment with a good prognosis and a very low recurrence rate. In this paper, two cases of angiomyofibroblastoma in the vaginal wall and vulva were reported. With a mini review, the clinical characteristics, pathological and immunohistochemical characteristics, diagnosis, treatment and prognosis of this disease were discussed.

Key words: Neoplasms,muscle tissue, Vulva, Vagina, Immunohistochemistry, Case reports, Angiomyofibro-blastoma

于晓枫, 郑晓丹, 蔡晓辉. 外阴阴道壁血管肌纤维母细胞瘤二例及文献复习[J]. 国际生殖健康/计划生育, 2021, 40(3): 198-201.

YU Xiao-feng, ZHENG Xiao-dan, CAI Xiao-hui. Two Cases Report of Angiomyofibroblastoma in the Vaginal Wall and Vulva, with A Mini Review[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(3): 198-201.

图/表 6

图1 病例1外阴肿物病理图 (HE×40) 注:肿瘤细胞密集区与稀疏区交替分布,肿瘤基质疏松水肿,呈黏液样。

图2 病例1外阴肿物病理图 (HE×40) 注:肿瘤境界清楚,见一薄纤维组织包膜。

图3 病例1外阴肿物免疫组织化学染色图 (EnVision×100) 注:免疫组化染色弥漫性强表达ER。

图4 病例2阴道壁肿物病理图 (HE×100) 注:薄壁血管被瘤细胞围绕呈簇状生长管壁小且薄,细胞无异型性。

图5 病例2阴道壁肿物病理图 (HE×200) 注:细胞核呈卵圆形,未见病理性核分裂相,散在炎细胞。

图6 病例2阴道壁肿物免疫组织化学染色 (EnVision×100) 注:免疫组化染色弥漫性强表达Desmin。

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