基于Web of Science数据库的近十年复发性流产的可视化分析

doi:10.12280/gjszjk.20220210

摘要/Abstract

摘要：

目的：运用知识图谱分析Web of Science核心合集数据库复发性流产的研究现状及发展趋势。方法：以复发性流产为主题检索Web of Science核心合集数据库,检索时间跨度为2012年1月—2022年1月。运用科学计量学工具CiteSpace（版本5.8.R3）及VOSviewer（版本1.6.17）对复发性流产的发文国家、机构、作者、关键词及被引文献进行可视化分析。结果：检索到3 116篇文献,去重与转化后纳入3 116篇文献。发文最多的国家是中国、美国、英国;主要研究机构是上海交通大学和复旦大学;中心度最高的被引文献主要与不明原因的复发性流产有关;高频关键词主要为expression、risk factor、natural killer cell等。结论：复发性流产病因复杂,发病机制不明,目前对母胎免疫耐受平衡关注较多,而遗传学因素及血栓前状态等其他病因也应深入研究。

关键词: 流产,习惯性, CiteSpace, VOSviewer, 可视化, Web of Science

Abstract:

Objective: To analyze the research status and development trend of recurrent spontaneous miscarriage(RSA) using the Web of Science core collection database and knowledge graphs. Methods: The Web of Science core collection database was searched for topics on recurrent miscarriages between January, 2012 and January, 2022. The scientometric tools CiteSpace (version 5.8.R3) and VOSviewer (version 1.6.17) were then used to visually analyze the publishing countries, institutions, authors, keywords, and cited papers for RSA. Results: A total of 3 116 articles were retrieved. After de-weighting and transformation, 3 116 articles were included. The countries with the most publications were China, USA and UK; the main research institutions were Shanghai Jiaotong University and Fudan University; the most cited literature with the highest centrality was mainly related to RSA of unknown origin; the high frequency keywords were mainly expression, risk factor and natural killer cell. Conclusions: The etiology of RSA is complex and the pathogenesis is unknown. More attention is currently paid to maternal-fetal immune tolerance balance, while other etiologies such as genetic factors and pre-thrombotic states should also be studied in depth.

Key words: Abortion, habitual, CiteSpace, VOSviewer, Visualization, Web of Science

潘婉晴, 张毅杰, 魏伟峰, 胡小芳. 基于Web of Science数据库的近十年复发性流产的可视化分析[J]. 国际生殖健康/计划生育, 2022, 41(5): 375-381.

PAN Wan-qing, ZHANG Yi-jie, WEI Wei-feng, HU Xiao-fang. Visual Analysis of Recurrent Spontaneous Miscarriage Based on the Web of Science Database over the Last 10 Years[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(5): 375-381.

图/表 10

参考文献 26

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排序	高频关键词	频次	中心度
1	expression	460	0.02
2	risk factor	406	0.02
3	natural killer cell	298	0.01
4	regulatory T cell	295	0.01
5	association	237	0.02
6	in vitro fertilization	218	0.01
7	cell	161	0.03
8	peripheral blood	142	0.02
9	polymorphism	140	0.03
10	implantation	138	0.02
11	antiphospholipid syndrome	130	0.02
12	preeclampsia	119	0.02
13	fetal loss	119	0.02
14	antiphospholipid antibody	113	0.02
15	gene	105	0.03
16	low molecular weight heparin	101	0.02

排序	高频关键词	频次	中心度
1	expression	460	0.02
2	risk factor	406	0.02
3	natural killer cell	298	0.01
4	regulatory T cell	295	0.01
5	association	237	0.02
6	in vitro fertilization	218	0.01
7	cell	161	0.03
8	peripheral blood	142	0.02
9	polymorphism	140	0.03
10	implantation	138	0.02
11	antiphospholipid syndrome	130	0.02
12	preeclampsia	119	0.02
13	fetal loss	119	0.02
14	antiphospholipid antibody	113	0.02
15	gene	105	0.03
16	low molecular weight heparin	101	0.02

聚类	S值	关键词
#0 Meta analysis	0.882	double blind、prevention、multicenter、trophoblast cells
#1 Treg cells	0.874	receptor、vascular endothelial growth factor、trophoblasts、Th17 cells
#2 Growth	0.906	mice、cytokine、embryo implantation、reproductive immunology
#3 DNA fragmentation	0.961	male infertility、sperm dna fragmentation、varicocele、sperm
#4 Natural killer cells	0.958	NK cell、regulatory T cells、peripheral blood
#5 Aneuploidy	0.905	comparative genomic hybridization、balanced translocation、preimplantation genetic screening、karyotyping
#6 Apoptosis	0.835	expression、hydatidiform mole、gene、microRNA
#7 Antiphospholipid syndrome	0.867	antiphospholipid antibodies、aspirin、heparin、pregnancy complications

聚类	S值	关键词
#0 Meta analysis	0.882	double blind、prevention、multicenter、trophoblast cells
#1 Treg cells	0.874	receptor、vascular endothelial growth factor、trophoblasts、Th17 cells
#2 Growth	0.906	mice、cytokine、embryo implantation、reproductive immunology
#3 DNA fragmentation	0.961	male infertility、sperm dna fragmentation、varicocele、sperm
#4 Natural killer cells	0.958	NK cell、regulatory T cells、peripheral blood
#5 Aneuploidy	0.905	comparative genomic hybridization、balanced translocation、preimplantation genetic screening、karyotyping
#6 Apoptosis	0.835	expression、hydatidiform mole、gene、microRNA
#7 Antiphospholipid syndrome	0.867	antiphospholipid antibodies、aspirin、heparin、pregnancy complications