国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2009, Vol. 28 ›› Issue (6): 383-386.

• 综述 • 上一篇    下一篇

卵巢微刺激促排卵方案在IVF周期的应用

陈佳;孙晓溪   

  1. 200030 上海交通大学医学院附属国际和平妇幼保健院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-11-15 发布日期:2009-11-15

Minimal Ovarian Stimulation for IVF

CHEN Jia-zhou;SUN Xiao-xi   

  1. The International Peace Maternity & Child Health Hospital， School of the Medicine， Shanghai JiaoTong University，Shanghai 200030，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-11-15 Online:2009-11-15

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摘要： 促排卵已经成为辅助生殖技术（ART）中的核心环节。目前超促排卵长方案即促性腺激素释放激素激动剂（GnRHa）抑制垂体联合相对大剂量外源性卵泡刺激素（FSH）在临床应用最广泛。但常规促排卵方案较复杂，费用高昂，用药时间长，大量雌激素的应用可造成卵巢过度刺激。临床有寻求更适宜促排卵方案的需求。由于GnRH拮抗剂（GnRHA）在临床应用，微刺激促排卵方案在体外受精（IVF）中应用逐渐广泛。该方案与常规促排卵方案最主要的区别在于前者在并不明显降低IVF成功率的前提下减少促性腺激素的用量，缩短刺激周期时间，降低卵巢过度刺激并发症的发生率。

关键词: 微刺激促排卵方案, 促性腺激素释放激素拮抗剂, 促性腺激素

Abstract: Ovarian stimulation has been a key component of assisted reproductive technologies （ART）. At present， a long gonadotrophin-releasing hormone agonist（GnRHa） pituitary suppression regimen combined with relatively high dose of exogenous follicle-stimulating hormone（FSH） remains the most frequent using for stimulation protocol. But currently used medication regimens for ovarian stimulation are complex， expensive， may require weeks of daily injections. Such protocol is also associated with the risk of complications such as ovarian hyperstimulation. It is necessary to seek better protocols for ovarian stimulation. Contribute to the use of gonadotrophin-releasing hormone antagonists（GnRHA）， the clinical application of mild ovarian stimulation IVF has been wildly opened. Comparing with routine ovarian stimulation protocol， the mild protocols use of lower dosage of gonadotrophin may shorten the treatment time and reduce the risk of complications of ovarian hyperstimulation which were not at cost of impaired pregnancy rate.

Key words: Minimal ovarian stimulation, Gonadotrophin-releasing hormone antagonist, Gonadotrophin