国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 141-144.

• 综述 • 上一篇    下一篇

细胞凋亡与神经管畸形

官臻，王建华，牛勃   

  1. 100020北京，首都儿科研究所生物技术科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15

Apoptosis and Neural Tube Defects

GUAN Zhen，WANG Jian-hua，NIU Bo   

  1. Department of Biotechnology， Capital Institute of Pediatrics，Beijing 100020，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15

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摘要： 在生物体的发育和自稳态的维持中，细胞凋亡发挥了重要作用。细胞凋亡有助于清除发育过程中多余和异常的细胞，以维持细胞增殖和凋亡的动态平衡，保证神经管的正常发育。在神经管发育期间，细胞凋亡容易受自身遗传、母体营养、环境理化因素的影响，这些因素可直接或间接干扰凋亡基因的正常表达，使细胞凋亡发生紊乱，打破细胞增殖和凋亡的动态平衡，最终影响机体的正常发育，使神经管闭合异常，导致神经管畸形的发生。综述细胞凋亡在神经管发育过程中的作用。

关键词: 细胞凋亡, 神经管缺损, 胚胎发育, 先天畸形, 基因

Abstract: Apoptosis may play an important role in organ development and self-balance maintenance.Apoptosis is beneficial to clear away the redundant and abnormal cells, which builts the new dynamic balancebetween cell proliferation and apoptosis. This mechanism is important for the neural tube development. Duringthe neural tube development, genetics, maternal nutrition, and environmental factors may affect apoptosis bydirect or indirect disturbance to the expression of key genes, by which apoptosis is affected. Apoptotic disorderleads to imbalance between cell proliferation and apoptosis, which interferes with normal development. Theclosed neural tube defects make up dysrhaphia and deformity. In this article，the role of apoptosis in the neural tube development was reviewed.

Key words: Apoptosis, Neural tube defects, Embryonic development, Congenital abnormalities, Genes