国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (4): 261-263.

• 综述 • 上一篇    下一篇

杀精抗菌双功能抗菌肽的研究进展

张 尉, 侯 丽 ,于和鸣   

  1. 100005 北京协和医学院研究生院（张 尉）；国家人口计生委科学技术研究所（侯 丽，于和鸣）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-07-15 发布日期:2013-07-15

Research Progress of the Antimicrobial Peptides with Dualfunctionality of Spermicide and Microbicide

ZHANG Wei，HOU Li，YU He-ming   

  1. Graduate School，Peking Union Medical College，Beijing 100005，China（ZHANG Wei）；National Research Institute for Family Planning，Beijing 100081，China（HOU Li，YU He-ming）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-07-15 Online:2013-07-15

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摘要： 抗菌肽（antimicrobial peptides）是广泛存在于生物体内的一类抵抗外源性病原微生物致病作用的防御性小分子多肽。抗菌肽拥有巨大的抗菌潜能和广泛的抗菌谱，以及安全、无毒副作用等特点，其中有些抗菌肽还展现了强有力的杀精避孕功能。综述Magainin，Dermaseptins，Nisin和Subtilosin 4种抗菌肽的杀精抗菌功能，为研制具有杀精抗菌双功能的生物制剂提供新的思路和来源。

关键词: 抗菌药, 肽类, 杀精子药, 避孕药, 男用, 综述

Abstract: Antimicrobial peptides are of important components of low-molecular weight peptides to defense organisms invasion. Antimicrobial peptides have many characteristics，such as the big antibacterial potential，broad antibacterial spectrum，safety，and non-toxic. Some of them also have powerful spermicidal and contraceptive potential. This review introduced the difunctionality of spermicide and microbicide of four antimicrobial peptides，including Magainin，Dermaseptins，Nisin and Subtilosin，which could provide us new ideas to develop the biological products with the difunctionality of spermicide and microbicide.

Key words: Anti-bacterial agents, Peptides, Spermatocidal agents, Contraceptive agents, male, Review