国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (5): 319-322.

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女性生殖内分泌与全身内分泌疾病

张以文   

  1. 100730 北京，中国医学科学院 北京协和医学院 北京协和医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-09-15 发布日期:2013-09-15

Female Reproduction and Systemic Endocrine Diseases

ZHANG Yi-wen   

  1. Department of Obstetric and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Science & Peking Union Medical College，Beijing 100730，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-09-15 Online:2013-09-15

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摘要： 现代内分泌系统的概念已涉及几乎全身组织或细胞。下丘脑促性腺激素释放激素（GnRH）-促性腺激素（Gn）脉冲分泌激活是启动卵巢轴功能的关键。其与4个下丘脑内分泌系统存在复杂的联系。神经内分泌免疫网络、神经内分泌营养调节网络也影响GnRH-Gn脉冲分泌或卵巢配子生成及性激素合成。介绍全身主要内分泌疾病对女性生殖的影响，并通过介绍一个心理神经内分泌失调疾病——功能性下丘脑性无排卵（functional hypothalamic anovulation，FHA），阐述应激对全身及女性生殖的影响。

关键词: 甲状腺激素, 催乳素, 糖皮质激素类, 生长激素, 胰岛素

Abstract: The modern endocrine system has been conceptually expanded to almost all tissues or cells of human body. Activation of the pulsatile secretion of hypothalamic GnRH-Pituitary Gn is the key step of initiating ovarian function, which is related to other four hypothalamic endocrine systems. Both the neuroendocrine-immune network and neuroendocrine-nutrition regulating network also impact the GnRH-Gn pulsatile secretion or ovarian gametogenesis, as well as steroidogenesis. This paper discussed the influence of systemic endocrine diseases on female reproduction，and elucidated the effects of stress on the systemic endocrine organs and ovarian axis by a psychoneuroendocrine disorder, functional hypothalamic anovulaton.

Key words: Thyroxine, Prolactin, Glucocorticoids, Growth hormone, Insulin