国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2018, Vol. 37 ›› Issue (2): 93-96.

• 论著 •    下一篇

女性乙型肝炎病毒感染对冷冻胚胎移植结局的影响

汪厉思，胡丽娜，张觇宇，李桑琳，何帆   

  1. 400010  重庆医科大学附属第二医院妇产科生殖医学中心
  • 收稿日期:2017-12-25 修回日期:2018-03-08 出版日期:2018-03-15 发布日期:2018-03-15
  • 通讯作者: 何帆，E-mail：dr_hefan@163.com E-mail:dr_hefan@163.com

Effects of Hepatitis B Virus Infection on Outcomes after Frozen-Thawed Embryo Transfer  

WANG Li-si，HU Li-na，ZHANG Chan-yu，LI Sang-lin，HE Fan   

  1. Reproductive Medicine Center，Department of Obstetrics and Gynecology，The Second Affiliated Hospital of Chongqing Medical University，Chongqing 400010，China
  • Received:2017-12-25 Revised:2018-03-08 Published:2018-03-15 Online:2018-03-15
  • Contact: HE Fan，E-mail：dr_hefan@163.com E-mail:dr_hefan@163.com

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摘要： 目的：探讨女性乙型肝炎病毒（HBV）感染与冷冻胚胎移植（FET）结局的相关性。方法：回顾性分析HBV感染组（女方血清HBsAg阳性、男方血清HBsAg阴性）和对照组（双方血清HBsAg阴性）的基线特征和FET周期数据。应用多因素Logistic回归分析女性HBV感染和临床妊娠的相关性。结果：共纳入93个FET周期，HBV感染组31个周期，对照组62个周期。2组患者的基线特征差异无统计学意义（P＞0.05）。HBV感染组的临床妊娠率和胚胎着床率虽高于对照组，但差异无统计学意义（45.2% vs. 40.3%，P=0.656；31.3% vs. 25.0%，P=0.361）。多因素Logistic回归分析结果显示，女性HBV感染与FET周期临床妊娠无相关性（OR=1.219，95%CI=0.510～2.911，P=0.656）。结论：女性HBV感染不影响FET周期的临床妊娠率。

关键词: 肝炎病毒, 乙型, 冷冻胚胎移植, 临床妊娠

Abstract: Objective：To investigate the effects of female hepatitis B virus (HBV) infection on outcomes after frozen-thawed embryo transfer (FET). Methods: The baseline characteristics and data of FET cycles in both the HBV group (couples with an HBsAg-positive female partner and an HBsAg-negative male partner) and the control group (couples with both HBsAg-negative partner) were retrospectively analyzed. Multivariate logistic regression was used to test for the association between clinical pregnancy and maternal HBV infection. P＜0.05 was considered statistically significant. Results: A total of 93 FET cycles were included in this study, including 31 cycles in the HBV group and 62 cycles in the control group. There were no significant differences in those baseline characteristics between the two groups (P＞0.05). The HBV group had mildly higher clinical pregnancy rate (45.2% vs. 40.3%, P=0.656) and embryo implantation rate (31.3% vs. 25.0%, P=0.361) when compared with the control group. Multivariate logistic regression analysis showed that maternal HBV infection was not associated with clinical pregnancy in FET cycles (OR=1.219, 95%CI=0.510-2.911, P=0.656). Conclusions: Maternal HBV infection had not adverse effect on clinical pregnancy rate after FET.

Key words: Hepatitis B virus, Frozen-thawed embryo transfer, Clinical pregnancy

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