国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (2): 116-119.

• 论著 • 上一篇    下一篇

补中益气颗粒联合多糖铁复合物治疗妊娠期缺铁性贫血疗效和安全性分析

周振昭，吴立明，陈宇   

  1. 518101 广东省深圳市，暨南大学附属深圳市宝安区妇幼保健院药剂科
  • 收稿日期:2018-10-08 修回日期:2019-01-21 出版日期:2019-03-15 发布日期:2019-03-15

Efficacy and Safety of Buzhong Yiqi Granule Combined with Polysaccharide Iron Complex in the Treatment of Iron Deficiency Anemia during Pregnancy

ZHOU Zhen-zhao，WU Li-ming，CHEN Yu   

  1. Department of Pharmacy，Bao'an District Maternal and Child Care Center Affiliated of Jinan University，Shenzhen 518101，Guangdong Province，China
  • Received:2018-10-08 Revised:2019-01-21 Published:2019-03-15 Online:2019-03-15

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摘要： 目的：探讨补中益气颗粒联合多糖铁复合物治疗妊娠期缺铁性贫血（IDA）的临床疗效。方法：将120例妊娠期IDA患者按照随机数字表法分为2组，每组60例。对照组给予多糖铁复合物治疗，研究组给予补中益气颗粒联合多糖铁复合物治疗，均用药4周。比较2组治疗前后红细胞（RBC）计数、血红蛋白（Hb）含量、平均红细胞血红蛋白含量（MCH）、血清铁（SI）、血清铁蛋白（SF）、铁调素和可溶性转铁蛋白受体（sTfR），以及2组治疗总有效率、不良反应和不良妊娠结局发生率。结果：治疗后研究组RBC、Hb、MCH、SI和SF均高于对照组，铁调素和sTfR低于对照组，治疗总有效率高于对照组，差异均有统计学意义（均P＜0.05）。2组不良反应发生率和不良妊娠结局发生率差异无统计学意义（P＞0.05）。结论：补中益气颗粒联合多糖铁复合物可有效改善铁代谢，治疗妊娠期IDA效果显著，安全性较好。

关键词: 贫血, 缺铁性, 孕妇, 多糖类, 胶囊, 补中益气

Abstract: Objective：To investigate the clinical effect of Buzhong Yiqi granules combined with polysaccharide-iron complex on the iron deficiency anemia (IDA) during pregnancy. Methods：120 pregnant women with IDA were divided into two groups according to the digital random table method, with 60 cases in each group. The control group was treated with polysaccharide-iron complex. The BY-treatment group was treated with Buzhong Yiqi granule (BY) combined with polysaccharide-iron complex. The red blood cell (RBC) count, hemoglobin (Hb), mean hemoglobin (MCH), serum iron (SI), serum ferritin (SF), hepcdin and transferrin receptor (sTfR) were compared between the two groups, before and after treatment. The total effective rate, the incidence of adverse reactions and the outcome of pregnancy were also compared. Results：RBC, Hb, MCH, SI, SF of the BY-treatment group were higher than those of the control group, while hepcdin and sTfR were lower than those of the control group, and the total effective rate was higher than that of the control group (all P＜0.05). There was no significant difference in the incidence of adverse reactions and the outcomes of adverse pregnancy between the two groups (P＞0.05). Conclusions：Buzhong Yiqi granule combined with polysaccharide iron complex can effectively improve iron metabolism, and it is effective and safe in the treatment of IDA during pregnancy.

Key words: Anemia, iron-deficiency, Pregnant women, Polysaccharides, Capsules, Invigorating spleen reinf qi