国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2020, Vol. 39 ›› Issue (4): 276-279.

• 论著 • 上一篇    下一篇

睡眠障碍与多囊卵巢综合征相关性的Meta分析

顾方韵，侯丽辉，夏小焱，孙淼，李妍，郝松莉   

  1. 150040  哈尔滨，黑龙江中医药大学（顾方韵，夏小焱）；黑龙江中医药大学附属第一医院（侯丽辉，孙淼，李妍，郝松莉）
  • 收稿日期:2020-03-24 修回日期:2020-04-30 出版日期:2020-07-15 发布日期:2020-07-15
  • 通讯作者: 侯丽辉，E-mail：houlihui2007@sina.com E-mail:404443615@qq.com
  • 基金资助:
    国家中医药管理局2014年全国名老中医药专家传承工作室建设项目（2014-9-10）；国家自然科学基金（81804138）；国家中医药管理局2015年度国家中医临床研究基地业务建设科研专项课题（JDZX2015059）

Association of Sleep Disturbances and Polycystic Ovary Syndrome: A Meta-Analysis

GU Fang-yun，HOU Li-hui，XIA Xiao-yan，SUN Miao，LI Yan，HAO Song-li   

  1.  Heilongjiang University of Chinese Medicine，Harbin 150040，China（GU Fang-yun，XIA Xiao-yan）；First Affiliated Hospital，Heilongjiang University of Chinese Medicine，Harbin 150040，China（HOU Li-hui，SUN Miao，LI Yan，HAO Song-li）
  • Received:2020-03-24 Revised:2020-04-30 Published:2020-07-15 Online:2020-07-15
  • Contact: HOU Li-hui，E-mail：houlihui2007@sina.com E-mail:404443615@qq.com

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摘要： 目的：系统评价睡眠障碍与多囊卵巢综合征（PCOS）的相关性。方法：计算机检索中国期刊全文数据库（CNKI）、万方数据库、PubMed、Web of Science、The Cochrane Library、Embase数据库，搜集关于睡眠障碍与PCOS的病例-对照研究，检索时限为建库至2020年1月1日。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险，采用Stata 12.0软件进行Meta分析。结果：共纳入8个研究，包括1 735例PCOS患者和1 671例对照者。Meta分析结果显示：PCOS组匹兹堡睡眠质量指数（PSQI）评分（WMD=2.89，95%CI：0.13～5.64，P=0.040）及睡眠障碍发生率（OR=2.26，95%CI：1.02～4.97，P=0.044）均高于对照组。结论：睡眠障碍与PCOS有一定相关性，受纳入研究的数量和质量的限制，尚待更多高质量研究予以验证。

关键词: 多囊卵巢综合征；, 睡眠障碍；, 病例对照研究；, Meta分析；, 偏倚（流行病学）

Abstract: Objective: To review the association of sleep disturbances and polycystic ovary syndrome (PCOS). Methods：PubMed, Web of Science, The Cochrane Library, Embase, CNKI and Wan Fang Data databases were electronically searched to collect the case-control studies on the association of sleep disturbances and PCOS. Two reviewers independently screened literatures, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using Stata 12.0 software. Results：A total of 8 case-control studies were included, in which 1 735 patients were in the case group and 1 671 in the control group. The results of meta-analysis showed: there were significant differences between the two groups in PSQI scores (WMD=2.89, 95%CI: 0.13-5.64, P=0.040) and sleep disturbances frequency (OR=2.26, 95%CI: 1.02-4.97, P=0.044). Conclusions：The current evidence shows that sleep disturbances is associated with PCOS. Due to the limited quality and quantity of the included studies, more high quality studies are required to verify above conclusion.

Key words: Polycystic ovary syndrome；, Sleep disorders；, Case-control studies；, Meta-analysis；, Bias (epidemiology)