关键词: 肿瘤内皮细胞标志物1；, 重组融合蛋白质类；, 抗原, 肿瘤；, 卵巢肿瘤；, 诊断：, 治疗

Abstract: Ovarian cancer is a gynecological genital malignancy, with high incidence and high mortality. Because of the concealment of ovarian cancer and the lack of effective detection methods, the patients were found in the middle and late stage of the disease. Therefore, to improve the early diagnosis of ovarian cancer can effectively improve the prognosis and survival rate of patients. Tumor endothelial marker 1 (TEM1) is a newly-found tumor specific marker of ovarian cancer. TEM1 can be expressed on the surface of ovarian cancer cells, but not expressed or lowly expressed in normal tissues, suggesting that TEM1 is a potential target for the diagnosis and treatment of ovarian cancer. The specific antibody of TEM1 combined with imaging technology and genetic engineering technology has shown the excellent anti-tumor effect on ovarian cancer. At the same time, a large number of clinical trials based on the targeted TEM1 are being in progress. In this article, we review the discovery, structure and tissue expression of TEM1, and its research progress, in the diagnosis and treatment of ovarian cancer, in order to provide new ideas for the future treatment of ovarian cancer.

Key words: Tumor endothelial marker 1;, Recombinant fusion proteins;, Antigens, neoplasm, Ovarian neoplasms, Diagnosis;, Therapy