关键词: 非编码RNA；, RNA；, 子宫内膜容受性；, 子宫内膜；, 体外受精；, 胚胎移植；, 反复种植失败；, 治疗失败

Abstract: Non-coding RNA (ncRNA) is a type of functional RNAs that do not directly translate into proteins, and that appear to be involved in a variety of biological processes, including epigenetic regulation, cell differentiation and proliferation, chromatin remodeling, transcriptional activation, transcriptional interference, nuclear splicing regulation, mRNA degradation, and translation regulation. Recurrent implantation failure (RIF) is a bottleneck of the success rate of in vitro fertilization and embryo transfer (IVF-ET), therefore a research hotspot in reproductive medicine. In recent years, accumulating evidence has shown that the abnormal expressions of microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA) in the endometrium, oocytes and cumulus cells could lead to RIF by impairing the endometrial receptivity, synchronous development of embryo and endometrium and embryo quality. This article reviews the function and research progress of ncRNA related to recurrent implantation failure.

Key words: Non-coding RNA;, RNA;, Endometrial receptivity；, Endometrium, Fertilization in vitro;, Embryo transfer;, Recurrent implantation failure, Treatment failure