国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2017, Vol. 36 ›› Issue (5): 364-367.

• 论著 • 上一篇    下一篇

下丘脑垂体性闭经应用HMG联合小剂量hCG促排卵成功妊娠4例分析及文献回顾

王海燕，李北氢，谷祝君   

  1. 116037  大连市妇女儿童医疗中心生殖与遗传医学中心
  • 收稿日期:2017-05-31 修回日期:2017-08-21 出版日期:2017-09-15 发布日期:2017-10-13
  • 通讯作者: 李北氢，E-mail：1409158003@qq.com E-mail:1409158003@qq.com

Analysis of Ovarian Stimulation with HMG Combined with Low-dose hCG and Successful Pregnancy in 4 Patients with Hypogonadotropic Amenorrhea, and A Brief Review

WANG Hai-yan, LI Bei-qing, GU Zhu-jun   

  1. Reproductive and Genetic Medical Center, Dalian Municipal Women and Children′s Medical Center, Dalian 116037, China
  • Received:2017-05-31 Revised:2017-08-21 Published:2017-09-15 Online:2017-10-13
  • Contact: LI Bei-qing, E-mail: 1409158003@qq.com E-mail:1409158003@qq.com

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摘要： 目的：探讨下丘脑垂体性闭经患者应用人绝经期促性腺激素（HMG）联合小剂量人绒毛膜促性腺激素（hCG）的促排卵疗效。方法：对4例下丘脑垂体性闭经患者HMG联合小剂量hCG促排卵和单纯应用HMG促排卵进行比较，观察血清激素水平、卵泡生长发育及妊娠结局。结果：4例患者应用HMG联合小剂量hCG 8个周期和单纯应用HMG促排卵4个周期比较，新方案优势卵泡数1～4个，周期妊娠成功率50%，无卵巢过度刺激综合征发生，均成功足月分娩。结论：HMG联合小剂量hCG促排卵能够安全有效地应用于下丘脑垂体性闭经的患者，可减少优势卵泡的数目，减少多胎风险。由于例数较少，尚需大规模临床试验进一步证实。

关键词: 下丘脑垂体性闭经, 闭经, 下丘脑疾病；, 促性腺素类, 绒毛膜促性腺激素, 排卵诱导

Abstract: Objective：To investigate the effect of ovarian stimulation with HMG combined with low-dose of hCG on those inferlity patients with hypogonatropic hypogonadism and amenorrhea. Methods:  Four infertility patients with hypogonatropic hypogonadism and amenorrhea were treated with HMG and low-dose of hCG for two cycles after one treatment with only HMG for four cycle, as for their ovarian stimulation. Follicular development was monitored by vaginal ultrasound-B and serum sexual hormone. Results: Totally, there were 4 cycles of only HMG treatment, and 8 cycles of HMG+hCG treatment. Compared with the only HMG cycles, the HMG+hCG cycles had the number of dominant follicles between 1 and 4, the cumulating pregnancy rate 50%, no moderate and severe OHSS, and a term birth for every patient.  Conclusions: The protocol of HMG combined with low-dose of hCG can be tried in those infertility patients with hypogonatropic hypogonadism for ovarian stimulation. However, the safety and efficiency of this combined protocol should be tested by other clinical trials and large samples.

Key words: Hypogonadotropic hypogonadism, Amenorrhea, Hypothalamic diseases, Menotropins, Chorionic gonadotropin, Ovulation induction