国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 213-215.

• 信息窗口 • 上一篇    下一篇

出生缺陷环境因素内暴露研究方法和技术进展

胡 毅, 夏红飞, 马 旭   

  1. 100080 北京，国家人口计生委科学技术研究所遗传中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 马旭

Progress of Research Methods and Technology for Detecting Exposure of Environmental Factors that can Bring About Birth Defects

HU Yi, XIA Hong-fei, MA Xu   

  1. Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing 100081, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15
  • Contact: MA Xu

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摘要： 环境危险因素是导致出生缺陷的一个重要原因。随着检测技术的发展，对环境因素内暴露水平的检测越来越精准，同时，也对环境因素内暴露诱导的致畸效应和分子生物学效应有了明确的认识。综述出生缺陷环境危险因素及其内暴露来源、常见环境致畸物内暴露水平检测技术、利用动物模型研究环境污染物内暴露作用的方法和环境污染物内暴露致生物学效应研究方法。

关键词: 先天畸形, 环境因素, 内暴露, 技术

Abstract: Birth defects are important factors affecting the quality of the population and destroying the happiness of the family. Environmental risk factors can lead to many kinds of serious birth defects. With the development of detection techniques，the exposure levels of environmental pollutants can be detected more and more accurately. We also get better understanding of the molecular mechanism of environmental pollutants caused birth defects. This paper reviews the environmental risk factors leading to birth defects and where they come from. The technologies detecting some kinds of common environmental teratogens exposure levels，animal models and methods studying changes of biological function were also included.

Key words: Congenital abnormalities, Environment, Exposure in vivo, Technology