卵巢癌中蛋白翻译后修饰的研究进展

doi:10.12280/gjszjk.20230090

摘要/Abstract

摘要：

近年卵巢癌的诊治虽已取得较大进展，但其5年生存率不足47%，积极探索新的治疗方法或新靶点十分必要。蛋白翻译后修饰（post-translational modification，PTM）是蛋白质功能调节的重要方式，通过对前体蛋白进行翻译后加工，改变蛋白质的理化性质、构象和结合能力，从而影响蛋白质的活性、稳定性和功能等方面。目前针对卵巢癌的研究主要集中在磷酸化、乙酰化、O-GlcNAc糖基化、S-棕榈酰化和泛素化等PTM，通过调节多种蛋白质的功能，调控相关信号通路或影响其下游分子的表达，影响卵巢癌细胞的增殖、侵袭、凋亡、耐药及化疗敏感性等。综述PTM在卵巢癌中的研究进展，以期为卵巢癌的精准靶向治疗提供新的理论依据。

关键词: 卵巢肿瘤, 蛋白质加工，转译后, 磷酸化, 乙酰化作用, 糖基化, 脂化作用

Abstract:

Although great progress has been made in the diagnosis and treatment of ovarian cancer in recent years, the proportion of patients with the 5-year survival is still less than 47%. It is necessary to explore actively new treatment methods or new targets. Post-translational modification (PTM) is an important way to regulate protein function. It modifies the physical and chemical properties, conformation, and the binding ability of proteins through post-translational processing of precursor proteins, thereby affecting protein activity, stability and function. At present, the research on ovarian cancer mainly focuses on PTM such as phosphorylation, acetylation, O-GlcNAcylation, S-palmitoylation and ubiquitination, which affect the proliferation, invasion, apoptosis, drug resistance and chemotherapy sensitivity of ovarian cancer cells by regulating the function of a variety of proteins, regulating related signaling pathways or affecting the expression of downstream molecules. This review on the research progress of PTM in ovarian cancer may provide a new theoretical basis for the precise and targeted therapy of ovarian cancer.

Key words: Ovarian neoplasms, Protein processing, post-translational, Phosphorylation, Acetylation, Glycosylation, Lipoylation

曹颖, 张东, 应小燕. 卵巢癌中蛋白翻译后修饰的研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(4): 348-352.

CAO Ying, ZHANG Dong, YING Xiao-yan. Research Progress of Post-Translational Modification in Ovarian Cancer[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(4): 348-352.

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