国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (5): 362-364.

• 热点问题 • 上一篇    下一篇

实验室对特殊病例胚胎移植方式的选择

吴克良,刘辉,于官令,赵海滨,李梅,陈子江   

  1. 250021 济南,山东大学附属生殖医院,国家辅助生殖与优生工程技术研究中心,生殖内分泌教育部重点实验室,山东省生殖医学重点实验室者
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-09-15 发布日期:2012-09-15
  • 通讯作者: 陈子江

Embryo Transfer Strategies for Special Cases in ART Laboratory

WU Ke-liang,LIU Hui,YU Guan-ling,ZHAO Hai -bin,LI Mei,CHEN Zi -jiang   

  1. Center for Reproductive Medicine,Provincial Hospital Affiliated toShandong University;National Research Center for Assisted Reproductive Technology and ReproductiveGenectics;The Key Laboratory for Reproductive Endocrinology of Ministry of Education;Shandong ProvincialKey Laboratory of Reproductive Medicine,Jinan 250021,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-09-15 Online:2012-09-15
  • Contact: CHEN Zi -jiang

摘要: 随着辅助生殖技术(ART)的不断进步,临床妊娠率也在逐年上升;然而在临床实践中,多
胎妊娠尤其是三胎及三胎以上的妊娠居高不下。多胎妊娠母婴发生不良妊娠结局的概率显著增加。目前国
内外接受体外受精(IVF)治疗的患者都是自费的,为了提高妊娠机会,患者往往倾向于移植较多的胚胎,然
而在临床实践中风险总是与收益并存,为使IVF 的结局最优化,应该在保证临床妊娠率的前提下将风险降
至最低。另外在胚胎挑选方面仍存在很大的盲目性,因此针对不同的患者建立个性化的移植方案尤为重
要。研究结果表明,对于反应正常且优胚较多(逸6)的患者采用囊胚移植可以获得比较理想的临床妊娠率
并且可显著地降低多胎妊娠率;对于无优胚周期的患者采用囊胚移植的方式可以有效地提高移植率;对于
高龄患者辅助孵化(AH)可以改善其临床结局;对于高反应患者,囊胚解冻周期移植可能是更好的选择。

关键词: 胚胎移植, 妊娠, 多胎, 生殖技术, 辅助, 受精, 体外

Abstract: As the great advances in ART,the rate of clinical pregnancy has been gradually improved,while the rate of multiple pregnancies, especially 逸3 pregnancies, was at very high level. The probability ofadverse pregnancy outcomes significantly increases in multiple pregnancies. Recently,patients undergoing IVFwould like to implant more embryos due to the expectation of high pregnant rate and low expense of their own.However,the risks and benefits always coexist in clinical practice. To optimize the outcome of IVF,the risks must be minimized if the clinical pregnancy rate is not significantly affected. In addition,blindness exists in embryo selection. It is important to set upa personalized strategy of embryo transplantation for those differentIVF patients. For normal responders with over 6 good-quality embryos,the blastocyst transfer can obtain ideal clinical pregnancies with decreased multiple pregnancy rate. For patients without obtained good -quality embryos,good clinical outcome can be acquired using blastocyst transfer. Assisted hatching (AH)can markedly improve the clinical pregnancies of those elderly patients. For high responders,freezing-thawing embryo transfer (FET)may bea better choice.

Key words: Embryotransfer, Pregnancy, multiple, Reproductivetechniques, assisted, FertilizationinVitro