膜联蛋白A家族在母胎界面及不良妊娠中的作用

doi:10.12280/gjszjk.20240211

摘要/Abstract

摘要：

母胎界面对于胚胎成功植入以及随后的胎盘发育至关重要。近年研究发现，母胎界面存在丰富的膜联蛋白A（Annexin A，AnxA）家族。AnxA家族不仅调节母胎界面中滋养层细胞的生物学行为，还参与蜕膜化过程。因此，AnxA家族表达异常与一系列不良妊娠结局（如反复种植失败和反复妊娠丢失）有关。明确AnxA家族在母胎界面的作用，有助于更好地理解AnxA导致不良妊娠结局的作用机制，并为相关疾病的治疗提供新的靶点。就AnxA家族在母胎界面及不良妊娠中的可能作用进行总结，提示其可作为治疗不良妊娠结局的潜在方向。

关键词: 膜联蛋白质类, 胚胎植入, 流产，习惯性, 妊娠结局

Abstract:

The maternal-fetal interface is essential for successful embryo implantation and subsequent placental development. Many studies have showed that the maternal-fetal interface is rich in the annexin A (AnxA) family, and that AnxA family not only regulates the biological behavior of trophoblast cells at the maternal-fetal interface, but also participates in the metaphase reaction. Therefore, the aberrant expression of the AnxA family is associated with a range of adverse pregnancy outcomes, such as recurrent implantation failure and recurrent pregnancy loss. Clarifying the role of the AnxA family at the maternal-fetal interface will help to understand better the mechanism of action of AnxA leading to adverse pregnancy outcomes, and to provide new targets for the treatment of related diseases. The possible roles of the AnxA family at the maternal-fetal interface and in the related adverse pregnancy are summarized in this review, to show a potential direction of the treatment of adverse pregnancy outcomes.

Key words: Annexins, Embryo implantation, Abortion, habitual, Pregnancy outcomes

谢娱新, 王瑞雪, 陈梦娜, 储继军. 膜联蛋白A家族在母胎界面及不良妊娠中的作用[J]. 国际生殖健康/计划生育杂志, 2024, 43(5): 430-434.

XIE Yu-xin, WANG Rui-xue, CHEN Meng-na, CHU Ji-jun. The Role of Annexin A Family at Maternal-Fetal Interface and Related Adverse Pregnancy[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(5): 430-434.

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