国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (4): 253-256.

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高级糖基化终产物及其受体与女性生殖健康

杨冬梓,郭 静   

  1. 中山大学孙逸仙纪念医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 杨冬梓

Roles of the Advanced Glycation End Products （AGEs） and Its Receptors in Women's Reproductive Health

YANG Dong-zi，GUO Jing   

  1. Department of Obstetrics and Gynecology，Memorial Hospital of Sun Yat-Sen University，Guangzhou 510120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-07-15 Online:2012-07-15
  • Contact: YANG Dong-zi

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摘要： 葡萄糖及其他还原糖的醛基、酮基与蛋白质、脂肪、核酸的氨基部分在无酶条件下反应形成高级糖基化终产物（AGEs），随着机体衰老或伴有高血糖、胰岛素抵抗、氧化应激、炎症反应等病理状态时，体内AGEs加速形成并蓄积，通过结合其受体（RAGE）造成组织细胞损害。RAGE的可溶形式（sRAGE）作为“诱饵受体”对机体产生保护作用。近年来，关于AGEs及其受体在女性生殖健康领域内的相关研究备受瞩目。临床及基础研究表明，高水平AGEs与多囊卵巢综合征、子宫内膜异位症及辅助生殖技术中不良结局密切相关，并导致子痫前期、早产、妊娠期糖尿病的发生率显著升高。通过调整饮食结构、生活方式及靶向药物治疗降低AGEs水平并削弱其作用，有望成为保护女性生殖功能，改善不孕人群助孕结局的新途径。

关键词: 糖基化终产物, 高级, 多囊卵巢综合征, 子宫内膜异位症, 生殖技术, 辅助, 不育, 女（雌）性, 妊娠结局

Abstract: The advanced glycation end products （AGEs） are a group of reactive cross-linked molecules formed by the non-enzymatic glycation of proteins，lipids，and nucleic acids. AGEs product and accumulate quickly in condition of aging，hyperglycemia，insulin resistance，oxidative stress，inflammation，diabetes，atherosclerosis and other diseases. AGEs cause harmful effect on tissues and cells by binding to their receptor （RAGE）. A soluble isoform of RAGE （sRAGE） palys a protective role as a decoy receptor，which could be a new way to interfere with AGEs. In the past years，the roles of AGEs and RAGE in female reproductive health were studied with concern. The high level of AGEs was found to be related to polycystic ovary syndrome，endometriosis and poor outcome of ART. And the high level of AGEs may lead to high rates of preeclampsia，preterm birth and gestational diabetes. High level of AGEs can be lowered though life style modification and drug targeting to improve female reproductive function and ART outcomes in sterility women.

Key words: Glycosylation end products, advanced, Polycystic ovary syndrome, Endometriosis, Reproductive techniques, assisted, Infertility, female, Pregnancy outcome