白藜芦醇对卵巢颗粒细胞功能的调节

doi:10.12280/gjszjk.20240343

摘要/Abstract

摘要：

白藜芦醇（resveratrol，Res）是存在于植物中的天然多酚类化合物，其作为抗氧化剂，具有减轻细胞氧化损害、恢复细胞功能和促细胞增殖等作用。颗粒细胞是卵巢合成和分泌多种激素的主要功能细胞，对卵泡的生长、发育及胚胎质量至关重要，影响女性的卵巢功能及生育能力。研究发现，Res可以改善颗粒细胞的生理功能，减轻氧化应激及有害物质对颗粒细胞造成的损伤。Res在治疗颗粒细胞相关的生殖疾病中具有潜在应用价值，因为颗粒细胞影响卵母细胞的生长与成熟，进而影响卵巢功能及妊娠结局。通过综述Res对卵巢颗粒细胞的功能调节，以期为女性生殖相关疾病的治疗提供新思路。

关键词: 白藜芦醇, 粒层细胞, 卵巢, 女（雌）性泌尿生殖系统疾病, 不育, 女（雌）性, 氧化性应激, 颗粒细胞

Abstract:

Resveratrol (Res), a natural polyphenolic compound in plants, is a natural antioxidant that reduce cell oxidative damage, restore cell function and promote cell proliferation. Granulosa cells are the main functional cells of the ovary that synthesize and secrete a variety of hormones, which are important for the growth and development of follicles and the quality of embryos, and affect women′s ovarian function and fertility. Studies have found that Res can improve the physiological function of granulosa cells and reduce the cell damage caused by oxidative stress and harmful substances to granulosa cells. Res has been showed a potential value in the treatment of reproductive diseases related to granulosa cells, because granulosa cells affect the growth and maturation of oocytes, and then affect ovarian function and pregnancy outcome. This artide reviewes the regulation of ovarian granulosa cells function by Res in order to provide new ideas for the treatment of female reproduction-related diseases.

Key words: Resveratrol, Granulosa cells, Ovary, Female urogenital diseases, Infertility, female, Oxidative stress, Granulose cells

杨琴, 王涵婷, 曹媛媛, 周军, 王桂玲. 白藜芦醇对卵巢颗粒细胞功能的调节[J]. 国际生殖健康/计划生育杂志, 2024, 43(6): 524-528.

YANG Qin, WANG Han-ting, CAO Yuan-yuan, ZHOU Jun, WANG Gui-ling. Effect of Resveratrol on the Function of Ovarian Granulose Cells[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(6): 524-528.

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