国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (1): 60-63.

• 综述 • 上一篇    下一篇

SOCS3基因在人类疾病发生中的作用

刘忠慧，郝翠芳   

  1. 266071 青岛大学（刘忠慧）；烟台毓璜顶医院生殖医学中心（郝翠芳）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-01-15 发布日期:2015-01-15
  • 通讯作者: 郝翠芳

SOCS3 Gene and Human Diseases

LIU Zhong-hui，HAO Cui-fang   

  1. Qingdao University，Qingdao 266071，Shandong Province，China（LIU Zhong-hui）；Reproductive Medical Center，Yantai Yuhuangding Hospital，Yantai 264000，Shandong Province，China（HAO Cui-fang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-01-15 Online:2015-01-15
  • Contact: HAO Cui-fang

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摘要： 细胞因子信号通路抑制因子3（SOCS3）是多种细胞因子（如白细胞介素、干扰素、肿瘤坏死因子等）信号通路的负反馈调节因子。SOCS3主要通过酪氨酸激酶信号转导与转录活化因子（JAK-STAT）通路执行其在信号转导过程中的抑制作用。近年研究发现，SOCS3与糖尿病、多囊卵巢综合征、肿瘤、炎症和过敏反应等多种疾病有关。SOCS3或许可以作为某些疾病诊断及评估预后的分子指标，以及作为特定疾病的靶基因。

关键词: 细胞因子类, 衔接蛋白质类, 信号转导, STAT转录因子类, 糖尿病, 多囊卵巢综合征, 肿瘤, 细胞因子信号通路抑制因子3

Abstract: Suppressor of cytokine signaling 3（ＳＯＣＳ３）， ａ ｎｅｇａｔｉｖｅ ｆｅｅｄｂａｃｋ ｆａｃｔｏｒ ｏｆ ｓｉｇｎａｌｉｎｇ ｐａｔｈｗａｙｓ ｏｆ ｍａｎｙ ｃｙｔｏｋｉｎｅｓ（ｓｕｃｈ ａｓ ｉｎｔｅｒｌｅｕｋｉｎｓ， ｉｎｔｅｒｆｅｒｏｎｓ， ｔｕｍｏｒ ｎｅｃｒｏｓｉｓ ｆａｃｔｏｒ， ｅｔｃ．）， plays its suppressive roles mainly through activating the tyrosine kinase pathway and the JAK-STAT pathway. It was found that SOCS3 was involved in many diseases, such as diabetes, polycystic ovary syndrome, cancer, inflammatory, allergic reactions and many other diseases. So SOCS3 could be used as a molecular marker for the diagnosis and assessment of prognosis of those diseases, even as a potential target gene for some specific diseases.

Key words: Cytokines, Adaptor proteins, signal transducing, STAT transcription factors, Diabetes mellitus, Polycystic ovary syndrome, Neoplasms, Suppressor of cytokine signaling 3