国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (6): 438-441.

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环孢素A对滋养细胞生物学行为的良性调节作用

李大金, 唐传玲, 杜美蓉   

  1. 200011 上海，复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-11-15 发布日期:2013-11-15
  • 通讯作者: 李大金

The Favorable Modulation of Cyclosporin A on the Biological Behaviors of Trophoblast Cells

LI Da-jin,TANG Chuan-ling，DU Mei-rong   

  1. Hospital of Obstetrics and Gynecology，Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-11-15 Online:2013-11-15
  • Contact: LI Da-jin

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摘要： 环孢素A（CsA）是一种强效免疫抑制剂，在临床上被广泛应用于防治器官移植后排斥反应和治疗某些自身免疫性疾病。体外研究发现，低浓度CsA既能促进滋养细胞增殖、减少滋养细胞凋亡，也能增强滋养细胞的迁移与侵袭。体内研究发现，低剂量CsA可明显降低自然流产模型小鼠的胚胎吸收率，改善妊娠结局。这些研究结果提示，低剂量CsA对滋养细胞的生物学行为具有良性调节作用，有可能成为防治自然流产、子痫前期等滋养细胞功能异常导致的妊娠相关疾病的一种新策略。

关键词: 环孢菌素, 滋养层, 细胞增殖, 细胞凋亡, 细胞迁移, 细胞侵袭

Abstract: Cyclosporin A （CsA），one of the most powerful immunosuppressant，has been widely used to prevent organ rejection and treat certain autoimmune diseases. CsA at low concentrations can increase the proliferation and reduce the apoptosis of trophoblast cells，as well as promote the trophoblastic migration and invasion in vitro. The study in vivo has showed that administration with low dose CsA at the early stage of pregnancy can reduce fetal resorption rate and improve the pregnancy outcome in murine abortion-prone CBA/J×DBA/2 matings. These results above suggest that CsA appears to have favorable effect on the biological behaviors of trophoblast cell，and might be used as a unique therapeutics for miscarriage，preeclampsia，and other pregnancy-related diseases caused by trophoblast cell dysfunction.

Key words: Cyclosporine, Trophoblasts, Cell proliferation, Apoptosis, Cell migratior, Cell invasion