国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (4): 271-273.

• 综述 • 上一篇    下一篇

代谢组学及其在辅助生殖技术中的应用前景

刘卫卫,孙莹璞   

  1. 450052 郑州大学第一附属医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 孙莹璞

The Prospective of Metabonomics in Assisted Reproductive Technology

LIU Wei-wei，SUN Ying-pu.   

  1. Medical Centre of the First Affiliated Hospital of Zhengzhou University，Zhengzhou，450052， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15
  • Contact: SUN Ying-pu

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摘要： 提高“试管婴儿”种植率并降低多胎妊娠率是现代辅助生殖技术（ART）的目标。为此，检
测和优选配子及胚胎的方法是必不可少的，传统的形态学评估和植入前遗传学诊断技术虽然发挥了重要
的作用，但是，现阶段尚缺乏一种客观而精确的评价配子和胚胎的方法。代谢组学是20世纪90 年代发展
起来的一门新兴学科，是系统生物学的重要组成部分，其精髓是在给定时间和给定条件下定量分析一个
生物系统的细胞所有小分子的代谢物质。目前，国外关于代谢组学在辅助生殖技术中应用的报道虽然不
多，但应用前景备受关注。

关键词: 生殖技术, 辅助, 妊娠, 多胎, 胚胎移植, 质谱分析法, 磁共振波谱学

Abstract: To inerease the efficiency of the IVF procedure by improving implantation rate and
lowering the risks of multiple gestations are the primary goals of the current assisted reproduction techology
（ART）. These aims require a much improved gamete/embryo testing and selection procedure. Though the
current approaches of microscopy-based morphology evaluation and preimplantation genetic diagnosis（PGD）
play an impartant role on it, there is lack of an objective and non-invasive techniques to detect and select
gamete/embryo at present. Since its birth in the 1990s, metabonomics has become an important part of systems
biology. Its essence is the quantitative measurement of all low molecular weight metabolites in an organism’s
cells at a specified time under specific environmental conditions. There are not many reports about

Key words: Reproductive techniques, assisted, Pregnancy, multiple, Embryo transfer, Mass spectrometry, Megnetic resonance spectrosapy