国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (6): 454-457.

• 综述 • 上一篇    下一篇

含吲哚美辛宫内节育器中吲哚美辛的作用及其机制

修瑞杰, 顾向应   

  1. 300052 天津医科大学总医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 顾向应

Effect of Indomethacin Contained in the Indomethacin-releasing Intrauterine Device and Its Mechanism

XIU Rui-jie,GU Xiang-ying   

  1. Ｔｉａｎｊｉｎ Ｍｅｄｉｃａｌ Ｕｎｉｖｅｒｓｉｔｙ General Hospital， Ｔｉａｎjｉｎ ３０００52， Ｃｈｉｎａ
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-11-15 Online:2011-11-15
  • Contact: GU Xiang-ying

PDF (PC)

7271

摘要： 宫内节育器（IUD）是中国育龄妇女使用最广泛的避孕工具，经量增多、经间点滴出血是IUD的主要不良反应。含吲哚美辛的IUD不仅能发挥良好的避孕效果，而且能避免置器后经量增多、经间点滴出血的不良反应。大量研究表明，吲哚美辛能抑制哺乳动物排卵。因此，研究者对这类含有吲哚美辛IUD的作用机制有了新的认识和探讨空间，即含吲哚美辛的IUD是否有抑制女性排卵、抑制卵子受精的作用。

关键词: 宫内避孕器, 含药, 吲哚美辛, 避孕, 药理作用分子作用机制, 月经过多

Abstract: Intrauterine device（IUD） is the most widely used contraceptive method in fertile woman in China. The main side effects of IUD are hypermenorrhea and bit bleeding in menstrual interphase. Indomethacin-releasing IUD is a efficient contraceptive， efficaciously preventing those side effects. A lot of study suggested that indomethacin inhibited ovulation in mammals. It is necessary to study the effects of inclomthacin-releasing IUD and its new mechanism to clarify whether indomethacin-releasing IUD inhibit ovulation and fertilization in the human famale.

Key words: ntrauterine devices, medicated, Indomethacin, Contraception, Molecular mechanisms of pharmacological action, Menorrhagia