国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (5): 390-394.

• 综述 • 上一篇    下一篇

温度敏感性瞬时受体电位通道调节精子功能的研究进展

张晓柯，王晓烔，胡廉   

  1. 430030 武汉，华中科技大学同济医学院计划生育研究所
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-25 发布日期:2016-10-25
  • 通讯作者: 胡廉

Research Progress on the Regulation of Thermo-TRP Channels on Sperm Function

ZHANG Xiao-ke, WANG Xiao-tong, HU Lian   

  1. Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-25 Online:2016-10-25
  • Contact: HU Lian

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摘要： 精子胞内信号分子及精子膜上的离子通道在调节精子功能中发挥作用。细胞膜上的瞬时受体电位（transient receptor potential，TRP）通道通过调节细胞内离子浓度，影响细胞的各种生理功能。温度敏感性TRP通道可以将温度信号转化成生物学信号，其中TRPV1、TRPV2、TRPV3和TRPV4属于热敏感TRP通道，TRPM8和TRPA1属于冷敏感TRP通道。对精子功能调节作用的研究主要在于TRPV1通道和TRPM8通道。TRPV1通道和TRPM8通道分布于精子不同部位，通道激活后可升高精子胞内Ca2+浓度，调控精子运动、顶体反应、趋热性等。TRPV1通道还能在精子脱离输卵管上皮细胞的黏附过程中发挥作用。TRPV1通道配体结合位点的变化，会导致TRPV1通道功能障碍，可能影响雄性生育力。

关键词: TRPV阳离子通道, TRPM阳离子通道, 精子能动性, 顶体反应, 生育力

Abstract: The intracellular signaling molecules and membrane ion channels regulate the sperm function. The transient receptor potential (TRP) channels participate in various physiological processes through regulating the intracellular ion concentrations. The thermo-TRP channels are a group of the TRP channels which can convert the temperature signal into biological signal, including the heat-gated ion channels such as TRPV1, TRPV2, TRPV3 and TRPV4, and the cold-gated ion channels such as TRPM8 and TRPA1. TRPM8 and TRPV1 located in the different segments of the sperm are involved in calcium signaling pathway. The activated TRPM8 and TRPV1 can regulate sperm motility, acrosome reaction, thermotaxis, etc. TRPV1 can also induce sperm to release from oviductal epithelia cell adhesion. Besides, the change of TRPV1 ligand binding sites can lead to the dysfunction of TRPV1 channel, which might have negative effects on male fertility.

Key words: TRPV cation channels, TRPM cation channels, Sperm motility, Acrosome reaction, Fertility