国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (6): 519-523.

• 综述 • 上一篇    

男性避孕药研究及其进展

严俨，赵冉，徐奕玫，党学宁，刘悦，丁之德   

  1. 200025 上海交通大学医学院临床医学2013级（严俨，赵冉，徐奕玫，党学宁），解剖学与组织胚胎学系（刘悦，丁之德）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-12-25 发布日期:2016-12-25
  • 通讯作者: 丁之德

The Advances in Male Contraceptives

YAN Yan，ZHAO Ran，XU Yi-mei，DANG Xue-ning，LIU Yue，DING Zhi-de   

  1. Department of Clinical Medicine，Grade 2013（YAN Yan，ZHAO Ran，XU Yi-mei，DANG Xue-ning），Department of Anatomy，Histology and Embryology（LIU Yue, DING Zhi-de），School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-12-25 Online:2016-12-25
  • Contact: DING Zhi-de

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摘要： 处于研究阶段的男性避孕药主要分为激素类和非激素类，以及针对特异性抗原的男性免疫避孕疫苗。激素类避孕药已经过长期的药效实验研究，现主要集中于雄激素单用、合成雄激素以及雄激素与孕酮合用等方法。非激素避孕药作用的靶点有精子生成、精子活力以及睾丸非生殖细胞（睾丸间质细胞、Sertoli细胞）。非激素避孕药具有靶点专一性特征，使用时可能减少不良反应，并且起效快，但现阶段尚未进入临床应用。发现更多的作用新靶点，将为男性避孕药研发带来希望。

关键词: 避孕药, 男用, 精子, 疫苗, 避孕

Abstract: The male contraceptives can be mainly divided into three kinds: hormonal, non-hormonal and male contraceptive vaccines. Hormonal contraceptives have been developed through longtime pharmacological experiments and some clinical trials, including androgen alone, synthetic androgen, and the combination of androgen and progesterone, etc. The targets of those non-hormonal methods were spermatogenesis, sperm motility, non-germinal cells including Leydig cells and Sertoli cells. With the characteristic of target′s specificity, those non-hormonal methods can work with the rapid onset and the low side effects. However, they are still in the stage of preclinical study. Discovery of more targets will bring new hope for the development of male contraceptives.

Key words: Contraceptive agents, male, Spermatozoa, Vaccines, contraceptive