m6A甲基化修饰在生殖相关疾病中的研究进展

doi:10.12280/gjszjk.20230145

摘要/Abstract

摘要：

N⁶-甲基腺苷（N⁶-methyladenosine，m⁶A）甲基化修饰是真核生物最常见的RNA修饰，通过控制RNA代谢、选择性剪接、降解和翻译等过程调控基因表达和生物学功能。近年研究发现m⁶A甲基化修饰在生殖系统中发挥重要的调节作用，参与多囊卵巢综合征、子宫内膜异位症、早发性卵巢功能不全、子宫腺肌病等多种女性生殖内分泌疾病和女性生殖系统肿瘤的发生、发展。此外，m⁶A甲基化修饰还可以调节人类精子发生和睾丸功能，与男性少弱精子症和男性生殖系统肿瘤相关。提示m⁶A甲基化修饰可能是生殖相关疾病调控的新靶点。综述m⁶A甲基化修饰的作用机制及其在生殖相关疾病中的研究进展，对生殖相关疾病的诊断和治疗具有一定指导意义。

关键词: N⁶-甲基腺苷, 甲基化, 生殖器疾病，女（雌）性, 泌尿生殖系统肿瘤, 精子发生

Abstract:

N⁶-methyladenosine (m⁶A) methylation is the most common RNA modification in eukaryotes, which regulates gene expression and biological functions by controlling RNA metabolism, alternative splicing, degradation and translation. In recent years, it has been found that m⁶A methylation plays an important regulatory role in the reproductive system, and that m⁶A is involved in the occurrence and development of polycystic ovary syndrome, endometriosis, premature ovarian insufficiency, adenomyosis and other female reproductive endocrine diseases and female reproductive system tumors. In addition, m⁶A methylation modification can also regulate human spermatogenesis and testicular function, and m⁶A is associated with male oligoasthenospermia and male reproductive system tumors. Taken together, m⁶A methylation modification may be a new target for the regulation of reproductive-related diseases. In this article, we review the mechanism of m⁶A methylation modification and the research progress in reproductive-related diseases, which has certain guiding significance for the diagnosis and treatment of reproductive-related diseases.

Key words: N⁶-methyladenosine, Methylation, Genital diseases, female, Urogenital neoplasms, Spermatogenesis

周昕玥, 张安妮, 张学红. m⁶A甲基化修饰在生殖相关疾病中的研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(5): 392-397.

ZHOU Xin-yue, ZHANG An-ni, ZHANG Xue-hong. Research Progress of m⁶A Modification in Reproductive-Related Diseases[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(5): 392-397.

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m⁶A甲基化修饰在生殖相关疾病中的研究进展

Research Progress of m⁶A Modification in Reproductive-Related Diseases

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