Abstract:

A case of small cell neuroendocrine carcinoma originating in the endometrium was reported. The patient was a 59-year-old woman with postmenopausal vaginal bleeding and no significant abnormalities in the level of serum tumor markers. Pelvic magnetic resonance imaging (MRI) showed the thickening of endometrium with abnormal signals, the increased signals of fundus uteri, the uterine body junction zone and myometria with limited diffusion. On September 14, 2023, the patient underwent the single-hole transumbilical laparoscopic transabdominal total hysterectomy+transabdominal bilateral salpingotomy+transabdominal bilateral oophorectomy+retroperitoneal abdominal paraaortic lymph node dissection+transabdominal bilateral pelvic lymph node dissection+pelvic adhesion release+umbilical plastic surgery. As of December 2023, the patient has received four times of chemotherapy, the general condition was good, and no recurrence and metastasis were found. Endometrial small cell neuroendocrine carcinoma has a high degree of malignancy and poor prognosis, with non-specific clinical manifestations. Diagnosis mainly relies on pathological and immunohistochemical examinations. Early detection, diagnosis and personalized treatment are key to improving patient prognosis.

Key words: Endometrium, Carcinoma, neuroendocrine, Carcinoma, small cell, Diagnosis, Therapy, Prognosis