Lymphoepithelioma-Like Carcinoma of the Cervix: A Case Report

doi:10.12280/gjszjk.20250608

Abstract

Abstract:

Cervical lymphoepithelioma-like carcinoma (LEC) is a rare malignant tumor of the cervix, and its pathogenesis is still unclear. We report a case of 49-year-old female patient who presented with human papillomavirus 16 (HPV 16) infection and post-coital hemorrhage. She was diagnosed as papillary squamous cell carcinoma by histopathological biopsy under colposcope. She underwent laparoscopic transabdominal hysterectomy without uterine manipulator+bilateral adnexectomy+bilateral ovarian arteriovenous high ligation+pelvic lymph node dissection + tumor chemotherapy (intraperitoneal infusion of lobaplatin 50 mg). After surgery, she was diagnosed as cervical LEC by pathology and immunohistochemistry. The postoperative chemotherapy of adjuvant paclitaxel albumin+carboplatin was for a total of 6 cycles. No recurrence or metastasis was found through the follow-up until November 22, 2025. This case suggests that in HPV infection-related cervical tumors, the possibility of cervical LEC should be alerted. Pathological and immunohistochemical examinations are of great value in clarifying the diagnosis. Standardized surgical treatment combined with adjuvant chemotherapy may improve the prognosis of patients.

Key words: Uterine cervical neoplasms, Carcinoma, Lymphoepithelioma-like carcinoma, Human papillomavirus 16, Diagnosis, Therapy

LING Fei-fei, WANG Si-yao, LI Hong-li, LIU Chang. Lymphoepithelioma-Like Carcinoma of the Cervix: A Case Report[J]. Journal of International Reproductive Health/Family Planning, 2026, 45(2): 125-129.

Figures/Tables 2

References 19

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