Abstract: The development of in vitro fertilization-embryo transfer （ＩＶＦ－ＥＴ） with oocyte donation technology brings new hope for infertility patients with ovarian failure, as well as some new ethic problems for the whole society. The conflicts between the development of new technology and ethical problems should be integrated in consideration, which is the precondition of the reasonable application of this new technology. The hot ethic issues at present include the supply-demand imbalance of oocyte, donor compensation, requirement for donor and recipient, anonymous and child informed. We reviewed the previous publications and proposed some suggestions for these problems: to match gradually the supply-demand imbalance by increasing donation and developing oocyte-frozen technology, to plan the compensation according to the economic development and health-economic study, to adjust properly the requirement for donor-oocytes since the pregnant rate was increasingly improved, to evaluate comprehensively the psychology and economic state of recipient before IVF, and to reconsider accordingly the anonymous and child-informed regulations.

Key words: Oocyte donation, Fertilization in vitro, Embryo transfer, Ethics, medical