Abstract: Objective: To investigate the high risk factors，clinical characteristics and treatment of heterotopic pregnancy(HP) after in vitro fertilization and embryo transfer (IVF-ET)． Methods: Ten cases of HP after IVF-ET were analyzed retrospectively. Results: 9 of 10 HP patients suffered from tubal factor infertility. 8 of them had previous pelvic surgeries. 9 cases were diagnosed HP via ultrasound in the first visit. Operation was performed for all 10 cases，including 7 laparoscopes, 3 selective reductions. 8 patients got their healthy babies after operation. Conclusions: A history of tubal inflammatory disease and pelvic surgeries are the risk factors of HP. Transvaginal ultrasound is the first choice for HP diagnosis. Laparoscopy can be the safe and effective treatment for the HP of uterine pregnancy combined with heterotopic tubal or corneal pregnancy. Selective fetal reduction via transvaginal ultrasound can be recommended for the HP of uterine pregnancy combined with heterotopic cervical or cesarean scar pregnancy.

Key words: Case reports, Retrospective studies, Embryo transfer, Pregnancy, ectopic, Pregnancy, tubal, Fertilization in vitro