Abstract: Objective：To investigate the necessity and clinical outcomes of transabdominal multifetal reduction in those patients with dichorionic dianionic (DCDA) twin pregnancies after in vitro fertilization and embryo transfer (IVF-ET). Methods: A total of 248 DCDA twin pregnancies after IVF-ET were retrospectively analyzed, from Jan 2014 to Dec 2016. 59 patients received the transabdominal multifetal reduction (the reduced group), and 189 did not (the nonreduced group). The rate of midterm abortion, preterm birth, birth weight and birth week were compared between two groups. Results: Compared with the nonreduced group, the reduced group had higher birth weight [(2.92±0.58) kg vs. (2.40±0.42) kg], longer birth weeks (38.29±2.55 vs. 36.60±1.85), lower preterm birth rate (13.56% vs. 36.51 %) [34～36+6 weeks (10.17% vs. 29.10%), 28～33+6 weeks (3.39% vs. 7.41%)], and lower rate of low birth weight(14.55% vs. 53.63%). Conclusions: The transabdominal multifetal reduction is helpful to improve the clinical outcomes in those DCDA patients after IVF-ET.

Key words:  Fertilization in vitro, Embryo transfer, Pregnancy, Twins, dizygotic, Pregnancy reduction, multifetal