Abstract: Objective：To investigate the effect of hemabate on the hemostasis and oxidative stress in patients with placenta previa who undergoing cesarean delivery. Methods: Ninety-eight patients with placenta previa who undergoing cesarean delivery and postpartum hemorrhage in our hospital from January 2015 to February 2017 were retrospectively analyzed. According to the treatment methods, they were divided into the control group (51 cases) and the observation group (47 cases). The control group received the intrauterine packing hemostasis, and the observation group received a hemabate injection (250 μg) in corpus uteri besides the packing hemostasis. The bleeding volume, oxidative stress level and stress hormone were tested. Results: The blood loss in operation, 2 h postpartum and 24 h postpartum in the observation group were significantly lower than those in the control group (P＜0.05). The postoperative levels of serum ROS and MDA in both groups were significantly higher than the preoperative levels, and the postoperative levels of SOD and CAT were lower than the preoperative levels (P＜0.05). The postoperative levels of ROS and MDA in the observation group were significantly lower than those in the control group, and the postoperative levels of SOD and CAT were higher in the observation group than in the control group (all P＜0.05).  The postoperative levels of NE, E and Cor in both groups were significantly higher than those preoperative levels, while the postoperative levels of NE, E and Cor in the observation group were lower than those in the control group (all P＜0.05). Conclusions: Hemabate injection in corpus uteri as the adjuvant therapy of pre-placental hemorrhage can effectively reduce the blood loss and oxidative stress, suggesting the potential application of hemabate.

Key words: Hemabate, Carboprost, Postpartum hemorrhage, Placenta previa, Cesarean section, Oxidative stress