Abstract: Objective：To investigate the effect of cytomegalovirus (CMV) infection on the pregnancy outcomes of IVF/ICSI treatment. Methods：The data of 59 536 patients who underwent ART treatment in our center between August 2005 and January 2018 were retrospectively analyzed. These patients were divided into two groups: the CMV IgG positive group (n=94) and the CMV IgG negative group (n=26 483). The pregnancy outcomes were compared accordingly. Results：There were no significantly differences in the age, infertile duration, body mass index, base level of FSH between the two groups (all P＞0.05). The number of retrieved oocytes, the number of 2PN after IVF, the rate of biochemical pregnancy, and the rate of clinical pregnancy in the CMV IgG positive group were significantly lower than those in the CMV IgG negative group (all P＜0.05). Conclusions：The number of retrieved oocytes, the number of 2PN after IVF, the rate of biochemical pregnancy, and the rate of clinical pregnancy could be lowered in those patients with the history of CMV infection. The CMV positive infection may affect the clinical outcomes of IVF/ICSI treatment.

Key words: Cytomegalovirus infections, Immunoglobulin G, Fertilization in vitro, Embryo transfer, Pregnancy outcome