Abstract: Malignant mesothelioma (MM) is a clinically rare mesothelial cell origin tumor with high malignancy. It is more common in the pleural cavity and rare in the ovary. It is difficult to diagnosis before surgery and easy to confused with other malignant tumors of ovary, primary malignant mesothelioma of peritoneum, reactive mesothelioma and malignant tumors of gastrointestinal tract, therefore the diagnosis mostly depends on the postoperative pathology and is usually late with poor prognosis, to which clinicians must pay enough attention. In order to improve the understanding of the disease, we now analyze the data of a patient with ovarian epithelioid malignant mesothelioma, review the relevant literatures, and further explore the etiology, clinical tissue performance, immunohistochemistry, treatment and prognosis of MM to deepen the clinician understanding of the disease and improve the ability of diagnosis and treatment.

Key words: Mesothelioma, Ovarian neoplasms, Immunohistochemistry, Diagnosis, Therapy, Case report