Abstract: Objective: To evaluate the incidence of congenital heart disease (CHD) among perinatal kids in China. Methods：English and Chinese databases were electronically searched, to get the studies on the prevalence of COH in China from the creation of databases to January 2020. Two investigators independently reviewed those included studies, extracted data and evaluated data quality. Stata 12.0 software was used for the meta-synthesis. Results：29 original literatures were screened, reporting 8 327 724 subjects. Meta-regression analyses revealed that the total incidence of CHD among perinatal kids of China was 2.9‰ (95%CI: 2.2‰-3.8‰). The subgrouped analysis showed that ventricular septal defect was the main subtype. The incidence of CHD in male perinatal kids (2.9‰) was higher than that in female perinatal kids (2.2‰). The incidence of perinatal CHD in urban (2.5‰) was higher than that in rural (1.1‰). This incidence in the south (3.5‰) was higher than that in the north (2.1‰). The incidence of perinatal CHD of maternal age ≥35 (2.8‰) was higher than that of maternal age ＜35 (2.0‰). This incidence decreased from 2007 to 2012, and then showed an increasing trend from 2012. Conclusions：The ncidence of COH among perinatal kids of China showed an increasing trend in recent years. More targeted interventions should be provided so as to reduce the incidence of CHD.

Key words: Heart disease, congenital；, Incidence；, China；, Pregnant women；, Meta-analysis