Abstract: Objective: To review the association of sleep disturbances and polycystic ovary syndrome (PCOS). Methods：PubMed, Web of Science, The Cochrane Library, Embase, CNKI and Wan Fang Data databases were electronically searched to collect the case-control studies on the association of sleep disturbances and PCOS. Two reviewers independently screened literatures, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using Stata 12.0 software. Results：A total of 8 case-control studies were included, in which 1 735 patients were in the case group and 1 671 in the control group. The results of meta-analysis showed: there were significant differences between the two groups in PSQI scores (WMD=2.89, 95%CI: 0.13-5.64, P=0.040) and sleep disturbances frequency (OR=2.26, 95%CI: 1.02-4.97, P=0.044). Conclusions：The current evidence shows that sleep disturbances is associated with PCOS. Due to the limited quality and quantity of the included studies, more high quality studies are required to verify above conclusion.

Key words: Polycystic ovary syndrome；, Sleep disorders；, Case-control studies；, Meta-analysis；, Bias (epidemiology)