Abstract: Mitochondria as a kind of organelle belonging to maternal inheritance provides energy for cell activity, and participates in the management of reactive oxygen species and the regulation of cell apoptosis. Granulosa cells, as the closest somatic cells to the oocyte, provide steroid hormone, cytokine and substrate of adenosine triphosphate synthesis for oocyte, and protect oocyte from oxidative stress damage, playing important roles in oocyte development and maturation. The mitochondrial function of granulosa cells and the interaction between granulosa cells and oocytes are necessary for normal development of oocytes. A body of evidence shows that the mitochondrial dysfunction of granulosa cells can reduce the production of adenosine triphosphate and biosynthetic intermediates, and then affect the normal development of oocytes. The recent literatures about the correlation between mitochondrial function of granulosa cells and oocyte development were reviewed in this paper.

Key words: Mitochondria；, DNA, mitochondrial；, Oocytes；, Granulosa cells；, Adenosine triphosphate；, Reactive oxygen species